The San Sano Hotel represents what it remains and, partly what it has been restored, of the medieval Suburb of the 1.100. Its history is tied up to that of the territory, particularly to Gaiole in Chianti, that during the centuries, has defined the peculiarities of it historical-insediative. From origin etrusco-Romans, the most florid period has been that medieval, of which preserve still today the order and some visible structures still on the spot.

As the rests of a stall of the 1.300, of the boundaries of the ancient block, part of a tower, of a wall, of a practicable piazzetta still, of a sink dated to the 1.260, still intact that belongs to the room n. 8, denominated for the note "The sink." Traces of important fortifications bring us to the centuries XI-XIII, period which the territory enters to belong to the Republic in Florence, becoming in the XIII I exempt century " it Ties of the Chianti", to the border between Siena and Florence. After various vicissitudes of devastations and invasions from the senesis, that tried to take possession of what had become a main point and strategic I untie in the Florentine hinterland, only from the 1.555 in then Gaiole and San Cure they enjoy of some centuries of calm. Period in which, with the government of the Granduchis of the Physicians, it devoted us to the based economy on the agriculture and particularly to the production of the wine. The first historical document in which wine is mentioned white Chianti and its denomination is of 1368, while that in which wine is denominated red Chianti in the 1.427. In the 1.536 the Chianti is denominated as important wine on the table of the Popes. In the seven hundred one her" League of the Chianti" it became common autonomous, after the advent of the Dukes of Lorena and in the 1.861 the king Vittorio Emanuele of Savoia, attached Gaiole in Chianti and his/her territory to the kingdom of Italy.